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GARDASIL®

Quadrivalent Human Papillomavirus (Types 6, 11, 16, and 18) Recombinant Vaccine


Glossary

Anal cancer

HPV infection is strongly associated with anal cancer and the precancerous anal lesions that precede cancer. Most anal cancers are squamous cell carcinoma and 80-90% of these cancers are HPV positive. HPV types 16 and 18 are the most commonly associated types.

Abnormal and precancerous cervical, vulvar and vaginal cells

Abnormal and precancerous cervical cells are cells in the lining of the cervix that have changed in appearance. The more severe the cervical abnormality, the more likely it is that cervical cancer could develop in the future. Abnormal and precancerous vulvar and vaginal cells are cells in the lining of the vulva and vagina that have changed in appearance. The more severe the vulvar or vaginal abnormality, the more likely it is that vulvar or vaginal cancer could develop in the future.

Abnormal and precancerous anal lesions

Abnormal anal cells are cells in the lining of the anus that have changed in appearance. The more severe the anal abnormality, the more likely it is that anal cancer could develop in the future.

Cervical cancer

Cervical cancer is cancer of the cervix, the lower part of the uterus that connects to the vagina. It can be a result of certain high risk types of HPV. Learn more about cervical cancer.

Cervix

The cervix is the lower part of the uterus that connects to the vagina.

Genital HPV (human papillomavirus)

About 30 to 40 types of HPV are known as genital HPV since they affect the genital area. Learn more about HPV.

Genital warts

Genital warts are usually flesh-coloured growths that are caused by certain types of HPV. Learn more about genital warts.

HPV

HPV stands for Human Papillomavirus, a common virus that affects both females and males. There are more than 100 types of HPV and most often it does not cause any symptoms and goes away on its own. Others can cause diseases of the genital area.

Pap test

A Pap test, also known as a Pap smear, is part of the gynecological exam and helps detect abnormal cells in the lining of the cervix before they have a chance to become precancers or cervical cancer. Learn more about Pap tests.

Precancers

Precancers are highly abnormal cervical cells that have a high likelihood of becoming cervical cancer.

Uterus

The uterus is a muscular organ located in the pelvic cavity of females in which the fertilized egg implants and develops. It is also called the womb.

Vagina

The vagina is a 3- to 4-inch tube. Its upper part ends at the cervix and the lower part opens to the outside onto the vulva, the external female genitals.

Vaginal Cancer

A disease in which cancer cells form in the vagina (tube from vulva to cervix).

Vulva

The external female genitals.

Vulvar Cancer

Cancer in which the tumour is in the vulva (outer part of vagina).


IMPORTANT INFORMATION ABOUT GARDASIL®

In girls and women ages 9 to 45, GARDASIL® helps prevent infection caused by HPV types 6, 11, 16 and 18 and the following diseases associated with the HPV types included in the vaccine: cervical, vaginal, and vulvar cancers caused by HPV types 16 and 18; abnormal and precancerous vaginal and vulvar lesions, abnormal and precancerous cervical lesions as found in Pap tests, caused by types 6, 11, 16 and 18; and genital warts caused by types 6 and 11.

In girls and women ages 9 to 26, GARDASIL® also helps protect against anal cancer caused by HPV types 16 and 18, and abnormal and precancerous anal lesions caused by types 6, 11, 16 and 18.

In boys and men ages 9 to 26, GARDASIL® helps protect against infection caused by HPV types 6, 11, 16 and 18 and the following diseases associated with the HPV types included in the vaccine: anal cancer caused by HPV types 16 and 18, genital warts caused by types 6 and 11, and abnormal and precancerous anal lesions caused by types 6, 11, 16 and 18.

GARDASIL® helps prevent these diseases, but it does not treat them. And just like all vaccines, GARDASIL® may not fully protect everyone who gets it. GARDASIL® does not protect against all types of HPV. Duration of protection continues to be studied. GARDASIL® does not protect against other sexually transmitted infections.

Even if vaccinated with GARDASIL®, it is still important for women to continue having regular Pap tests. Recipients of GARDASIL® should not discontinue anal cancer screening if it has been recommended by a healthcare provider. Vaccination with GARDASIL® is not recommended during pregnancy.

Like all vaccines, GARDASIL® may cause some side effects. GARDASIL® has been shown to be generally well tolerated in adults and children as young as age 9. The most commonly reported side effects included pain, swelling, itching, bruising and redness where the shot was given, fever, nausea, dizziness, headache, vomiting and pain in extremity.

Fainting has been reported. Fainting can occur after vaccination, most commonly among adolescents and young adults. Although fainting episodes are uncommon, vaccinees should be observed for 15 minutes after they receive GARDASIL®.

Allergic reactions that may include difficulty breathing, wheezing (bronchospasm), hives, and rash have been reported.

These were not all the side effects reported. If you notice any unusual or severe symptoms after receiving GARDASIL®, contact your healthcare professional as soon as possible.

Information about GARDASIL® is provided in the Consumer Information. To retrieve this information you will be re-directed to a page within our main Merck Website, which contains the Consumer Information.

Click here to go to the Gardasil® Consumer Information.

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